(R)-N-(5,5-difluoropiperidin-3-yl)benzamide

Base Information

Chemical Name:(R)-N-(5,5-difluoropiperidin-3-yl)benzamide
CAS No.:1611488-11-9
Molecular Formula:C₁₂H₁₄F₂N₂O
Molecular Weight:240.253
Hs Code.:

Synonyms:

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Chemical Property of (R)-N-(5,5-difluoropiperidin-3-yl)benzamide

Chemical Property:

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Technology Process of (R)-N-(5,5-difluoropiperidin-3-yl)benzamide

There total 14 articles about (R)-N-(5,5-difluoropiperidin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: C₂₇H₂₄F₂N₂O₃

: 1611488-11-9
(R)-N-(5,5-difluoropiperidin-3-yl)benzamide

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201302423

Reference yield:

: 1611488-04-0
(3R,5S)-(9H-fluoren-9-yl)methyl 3-((tert-butoxycarbonyl)amino)-5-hydroxypiperidine-1-carboxylate

: 1611488-11-9
(R)-N-(5,5-difluoropiperidin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 12 h / 0 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / water; 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 0.08 h / -20 °C / Inert atmosphere

5: piperidine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; diethylamino-sulfur trifluoride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/chem.201302423

Reference yield:

: 3398-22-9,30724-02-8
trans-4-hydroxyproline

: 1611488-11-9
(R)-N-(5,5-difluoropiperidin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: thionyl chloride / 77 h / 0 - 20 °C / Inert atmosphere; Reflux

2.1: triethylamine / dichloromethane / 5.25 h / 0 °C / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 14 h / 0 °C / Inert atmosphere

4.1: tetrabutylammoniun azide / acetonitrile / 1 h / 70 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

6.1: 1,4-dioxane / 20 h / 20 °C / Inert atmosphere

7.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 8 h / 0 - 100 °C / Inert atmosphere; Microwave irradiation

7.2: 1 h / 20 °C / Inert atmosphere; Microwave irradiation

8.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / Inert atmosphere

9.1: sodium hydrogencarbonate / water; 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere

10.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 12 h / 0 - 20 °C / Inert atmosphere

11.1: diethylamino-sulfur trifluoride / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

12.1: hydrogenchloride / water; 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere

13.1: triethylamine / dichloromethane / 0.08 h / -20 °C / Inert atmosphere

14.1: piperidine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; tetrabutylammoniun azide; sodium hydrogencarbonate; triethylamine; trifluoroacetic anhydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201302423