(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid

Base Information

Chemical Name:(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid
CAS No.:259532-12-2
Molecular Formula:C₂₉H₃₆FN₅O₅S
Molecular Weight:585.7
Hs Code.:

(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2<i>H</i>-pyrimidin-1-yl)-acetic acid

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Chemical Property of (5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid

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Technology Process of (5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid

There total 12 articles about (5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 224776-35-6
ethyl 3-(2-methoxypyrimidin-5-yl)acrylate

: 259532-12-2
(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: H₂; Et₃N / Pd/C / ethanol

2.1: NaH / 1,2-dimethoxy-ethane

3.1: K₂CO₃ / dimethylformamide

4.1: aq. NaOH

5.1: (COCl)2 / 1,2-dichloro-ethane

6.1: acetonitrile

7.1: dimethylformamide

7.2: NaOEt

8.1: iPrNEt / CH₂Cl₂

9.1: B-bromocatecholborane / CH₂Cl₂

10.1: K₂CO₃ / dimethylformamide

11.1: aq. NaOH / dioxane

With sodium hydroxide; oxalyl dichloride; bromocatecholborane; hydrogen; sodium hydride; potassium carbonate; N-isopropylethylamine; triethylamine; palladium on activated charcoal; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(01)00038-5

Reference yield:

: 259532-11-1
(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid ethyl ester

: 259532-12-2
(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane;
DOI:10.1016/S0960-894X(01)00038-5

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 259532-12-2
(5-{2-(4-fluoro-benzylsulfanyl)-1-[(methyl-octyl-carbamoyl)-methyl]-4-oxo-1,4-dihydro-pyrimidin-5-ylmethyl}-2-oxo-2H-pyrimidin-1-yl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iPrNEt / CH₂Cl₂

2: B-bromocatecholborane / CH₂Cl₂

3: K₂CO₃ / dimethylformamide

4: aq. NaOH / dioxane

With sodium hydroxide; bromocatecholborane; potassium carbonate; N-isopropylethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00038-5