2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

Base Information

Chemical Name:2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine
CAS No.:1316861-19-4
Molecular Formula:C₁₆H₁₄N₂S
Molecular Weight:266.367
Hs Code.:

Synonyms:

Suppliers and Price of 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
(2R)-2-Phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole ≥95%
100 mg
$ 210.00

Total 4 raw suppliers

Chemical Property of 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

Chemical Property:

Melting Point:145-147°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R)-2-Phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses This chiral isothiourea homobenzotetramisole ((R)-HBTM) developed by the Birman lab is an organocatalyst that has been used for kinetic resolution, determination of absolute configuration, and nucleophile-catalysed, Michael–aldol-b-lactonization (NCMAL). This same product was previously listed as L511730, and the complementary (S)-HBTM organocatalyst (900542) is also available.

Technology Process of 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

There total 5 articles about 2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136-95-8,102337-98-4,84293-42-5
2-amino-benzthiazole

: 1015248-96-0
2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

: 1316861-19-4
2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / acetonitrile / 0 °C / Inert atmosphere

2.1: sodium iodide / acetonitrile / 8 h / 0 - 80 °C / Inert atmosphere

3.1: tetrahydrofuran / -15 °C / Inert atmosphere

3.2: 0.5 h / -15 °C / Inert atmosphere

4.1: trifluoroacetic acid; triethylsilane / 6 h / -15 °C / Inert atmosphere

5.1: Resolution of racemate; Inert atmosphere

With triethylsilane; sodium carbonate; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; acetonitrile; 3.1: |Grignard Reaction;
DOI:10.1021/jo400603n

Reference yield:

: 17326-07-7
3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidin-2-one

: 1015248-96-0
2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

: 1316861-19-4
2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -15 °C / Inert atmosphere

1.2: 0.5 h / -15 °C / Inert atmosphere

2.1: trifluoroacetic acid; triethylsilane / 6 h / -15 °C / Inert atmosphere

3.1: Resolution of racemate; Inert atmosphere

With triethylsilane; trifluoroacetic acid; In tetrahydrofuran; 1.1: |Grignard Reaction;
DOI:10.1021/jo400603n

Reference yield:

: 2877-36-3
β-chloropropionyl-2-aminobenzothiazole

: 1015248-96-0
2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

: 1316861-19-4
2-phenyl-3,4-dihydro-2H-benzo[4,5]thiazolo[3,2-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 0 - 80 °C / Inert atmosphere

2.1: tetrahydrofuran / -15 °C / Inert atmosphere

2.2: 0.5 h / -15 °C / Inert atmosphere

3.1: trifluoroacetic acid; triethylsilane / 6 h / -15 °C / Inert atmosphere

4.1: Resolution of racemate; Inert atmosphere

With triethylsilane; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; acetonitrile; 2.1: |Grignard Reaction;
DOI:10.1021/jo400603n