Technology Process of ER811261
There total 3 articles about ER811261 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid / water / 20 - 40 °C
2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 18 h / 20 °C
3.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 2 h
4.1: pyridinium trifluroacetate / dichloromethane / -20 - -10 °C
4.2: -20 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
7.1: tetrakis(triphenylphosphine) palladium(0); phenylsilane; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
With
hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium(0); phenylsilane; hydrogen; pyridinium trifluroacetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium hydroxide on carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 2 h
2.1: pyridinium trifluroacetate / dichloromethane / -20 - -10 °C
2.2: -20 - 20 °C
3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
5.1: tetrakis(triphenylphosphine) palladium(0); phenylsilane; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); phenylsilane; hydrogen; pyridinium trifluroacetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium hydroxide on carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 18 h / 20 °C
2.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 2 h
3.1: pyridinium trifluroacetate / dichloromethane / -20 - -10 °C
3.2: -20 - 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
6.1: tetrakis(triphenylphosphine) palladium(0); phenylsilane; triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C
With
hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium(0); phenylsilane; hydrogen; pyridinium trifluroacetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium hydroxide on carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;