(5Z)-5-hex-2-ynylidenefuran-2-one

Base Information

Chemical Name:(5Z)-5-hex-2-ynylidenefuran-2-one
CAS No.:23251-67-4
Molecular Formula:C₁₀H₁₀O₂
Molecular Weight:162.188
Hs Code.:
NSC Number:121218,101775
Metabolomics Workbench ID:127411
ChEMBL ID:CHEMBL2229361
Mol file:23251-67-4.mol

Synonyms:(Z)-Lachnophyllum lactone;81122-95-4;(5Z)-5-hex-2-ynylidenefuran-2-one;NSC121218;(Z)-Lachnophyllumlactone;MEGxp0_001829;CHEMBL2229361;ACon1_000578;(4Z)-LACHNOPHYLLUM LACTONE;NSC101775;AKOS040762948;NSC-101775;NSC-121218;NCGC00168944-01;23251-67-4

Suppliers and Price of (5Z)-5-hex-2-ynylidenefuran-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (5Z)-5-hex-2-ynylidenefuran-2-one

Chemical Property:

Vapor Pressure:0.0108mmHg at 25°C
Boiling Point:262.6°C at 760 mmHg
Flash Point:103.7°C
Density:1.191g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:162.068079557
Heavy Atom Count:12
Complexity:296

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC#CC=C1C=CC(=O)O1
Isomeric SMILES:CCCC#C/C=C\1/C=CC(=O)O1

Technology Process of (5Z)-5-hex-2-ynylidenefuran-2-one

There total 3 articles about (5Z)-5-hex-2-ynylidenefuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 81122-94-3
5-(1-Hydroxy-hex-2-ynyl)-5H-furan-2-one

: 23251-67-4
5-hex-2-ynylidene-5H-furan-2-one

Guidance literature:: With acetic anhydride; triethylamine; 4-pyrrolidin-1-ylpyridine; In dichloromethane; for 1h; Ambient temperature; E/Z ratio= 5:2;
DOI:10.1016/S0040-4039(01)82929-4

Reference yield:

: 27593-24-4
hex-2-ynal

: 23251-67-4
5-hex-2-ynylidene-5H-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 1M HCl / 1.) SnCl₄ / 1.) CH₂Cl₂, -78 deg C, 2 h 2.) -78 deg C to room temp.

2: 90 percent / Et₃N, (CH₃CO)2O / PPY / CH₂Cl₂ / 1 h / Ambient temperature; E/Z ratio= 5:2

With hydrogenchloride; acetic anhydride; triethylamine; tin(IV) chloride; 4-pyrrolidin-1-ylpyridine; In dichloromethane;
DOI:10.1016/S0040-4039(01)82929-4