Cyclohexanecarboxylic acid, 4-[(triphenylmethyl)thio]-, cis-

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 4-[(triphenylmethyl)thio]-, cis-
• CAS No.: 105676-10-6
• Molecular Formula: C₂₆H₂₆O₂S
• Molecular Weight: 402.557
• Mol file: 105676-10-6.mol

Synonyms:

Chemical Property of Cyclohexanecarboxylic acid, 4-[(triphenylmethyl)thio]-, cis-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 4-[(triphenylmethyl)thio]-, cis-

There total 3 articles about Cyclohexanecarboxylic acid, 4-[(triphenylmethyl)thio]-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.9%

trityl chloride (76-83-5) + cis-4-mercaptocyclohexanecarboxylic acid (105676-06-0,82001-54-5) → cis-4-(triphenylmethylthio)cyclohexanecarboxylic acid (105676-10-6)

Guidance literature:

With pyridine; In chloroform; for 72h; Ambient temperature;

Reference yield:

3,3-bis-(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2.>oct-5-ene (74346-66-0) → cis-4-(triphenylmethylthio)cyclohexanecarboxylic acid (105676-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.8 percent / hydrogen / 10percent Pd/C / ethyl acetate / 20 h / 2585.7 Torr / Ambient temperature

2: 1N HCl / Heating

3: 62.9 percent / pyridine / CHCl₃ / 72 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In chloroform; ethyl acetate;

Reference yield:

3,3-bis(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2>octane (105737-63-1) → cis-4-(triphenylmethylthio)cyclohexanecarboxylic acid (105676-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1N HCl / Heating

2: 62.9 percent / pyridine / CHCl₃ / 72 h / Ambient temperature

With pyridine; hydrogenchloride; In chloroform;

upstream raw materials:

trityl chloride

cis-4-mercaptocyclohexanecarboxylic acid

3,3-bis-(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2.>oct-5-ene

3,3-bis(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2>octane

Downstream raw materials:

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

cis-4-(triphenylmethylthio)-1-(p-nitrobenzyloxycarbonylamino)cyclohexane

(6S)-<(1R)-hydroxyethyl>-2-(cis-4-formimidoylaminocyclohexylthio)-(5R)-carbapen-2-em-3-carboxylic acid

(6S)-<(1R)-hydroxyethyl>-2-(cis-3-aminocyclohexylthio)-(5R)-carbapen-2-em-3-carboxylic acid

Refernces