6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde

Base Information

Chemical Name:6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde
CAS No.:1256820-83-3
Molecular Formula:C₈H₆F₃NO₂
Molecular Weight:205.136
Hs Code.:

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Chemical Property of 6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde

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Technology Process of 6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde

There total 6 articles about 6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1310948-34-5
(6-methoxy-5-(trifluoromethyl)pyridin-2-yl)methanol

: 1256820-83-3
6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 124236-37-9
5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester

: 1256820-83-3
6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic anhydride / N,N-dimethyl-formamide / 16.5 h / 0 - 60 °C / Inert atmosphere

3: silver carbonate / chloroform / 16 h / 60 °C / Inert atmosphere

4: methanol; lithium borohydride / 1 h / 0 - 20 °C

5: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With methanol; lithium borohydride; urea hydrogen peroxide adduct; Dess-Martin periodane; silver carbonate; trifluoroacetic anhydride; In dichloromethane; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1415899-18-1
1-oxy-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester

: 1256820-83-3
6-methoxy-5-(trifluoromethyl)pyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic anhydride / N,N-dimethyl-formamide / 16.5 h / 0 - 60 °C / Inert atmosphere

2: silver carbonate / chloroform / 16 h / 60 °C / Inert atmosphere

3: methanol; lithium borohydride / 1 h / 0 - 20 °C

4: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With methanol; lithium borohydride; Dess-Martin periodane; silver carbonate; trifluoroacetic anhydride; In dichloromethane; chloroform; N,N-dimethyl-formamide;