1H-Indene-2-acetic acid, 2,3-dihydro-5-methyl-1-phenyl-, trans-

Base Information

• Chemical Name: 1H-Indene-2-acetic acid, 2,3-dihydro-5-methyl-1-phenyl-, trans-
• CAS No.: 105677-60-9
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.34
• Mol file: 105677-60-9.mol

Synonyms:

Chemical Property of 1H-Indene-2-acetic acid, 2,3-dihydro-5-methyl-1-phenyl-, trans-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indene-2-acetic acid, 2,3-dihydro-5-methyl-1-phenyl-, trans-

There total 2 articles about 1H-Indene-2-acetic acid, 2,3-dihydro-5-methyl-1-phenyl-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-hydroxy-5-methyl-trans-2-indanylacetic acid (105677-59-6) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 5-methyl-1-phenyl-trans-2-indanylacetic acid (105677-60-9)

Guidance literature:

With aluminium trichloride; In nitrobenzene; 1.) 0 deg C, 3 h, 2.) r.t., 30 min;

Reference yield:

2-(5-Methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)acetic acid (16304-71-5) → 5-methyl-1-phenyl-trans-2-indanylacetic acid (105677-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaBH₄, 2.) 6 N HCl / 1.) alkaline solution, 2.) reflux

2: 65 percent / AlCl₃ / various solvent(s); nitrobenzene / 1.) 0 deg C, 3 h, 2.) r.t., 30 min

With hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; In nitrobenzene;

upstream raw materials:

1-hydroxy-5-methyl-trans-2-indanylacetic acid

benzene

2-(5-Methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)acetic acid

Refernces