AMinopterin-α-hyrazide

Base Information

• Chemical Name: AMinopterin-α-hyrazide
• CAS No.: 118359-33-4
• Molecular Formula: C₁₉H₂₂N₁₀O₄
• Molecular Weight: 454.448
• Mol file: 118359-33-4.mol

Synonyms:

Chemical Property of AMinopterin-α-hyrazide

Chemical Property:

• PKA: 3.56±0.10(Predicted)
• Density: 1.555±0.06 g/cm3(Predicted)

Purity/Quality:

Aminopterin-α-hyrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Aminopterin-α-hyrazide, is derivative of Aminopterin (A628850), which is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.

Technology Process of AMinopterin-α-hyrazide

There total 1 articles about AMinopterin-α-hyrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ECO746 (1312753-43-7) → C19H22N10O4 (118359-33-4)

Guidance literature:

With diothiothreitol; at 20 ℃; pH=7.4; aq. phosphate buffer;

DOI:10.1016/j.bmcl.2010.12.085

upstream raw materials:

ECO₇₄₆

Refernces