difluoro-(3-methyl-phenyl)-phosphine oxide

Base Information

• Chemical Name: difluoro-(3-methyl-phenyl)-phosphine oxide
• CAS No.: 769-91-5
• Molecular Formula: C₇H₇F₂OP
• Molecular Weight: 176.103
• Mol file: 769-91-5.mol

Synonyms:

Chemical Property of difluoro-(3-methyl-phenyl)-phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of difluoro-(3-methyl-phenyl)-phosphine oxide

There total 4 articles about difluoro-(3-methyl-phenyl)-phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-bromotoluene (591-17-3) → difluoro-(3-methyl-phenyl)-phosphine oxide (769-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Mg, iodine, 2) (Et₂N)2PCl / 1) ether, 0 deg C, 2) 25 deg C

2: NaF / tetrahydrothiophene 1,1-dioxide / 1) 120-140 deg C, 2) 25 deg C

With bis(diethylamino)chlorophosphine; iodine; sodium fluoride; magnesium; In sulfolane;

Reference yield:

m-methylphenylphosphorus dichloride (5510-88-3) → difluoro-(3-methyl-phenyl)-phosphine oxide (769-91-5) + C7H7F2P (127599-95-5)

Guidance literature:

With sodium fluoride; In sulfolane; 1) 120-140 deg C, 2) 25 deg C;

Reference yield:

C7H7F2P (127599-95-5) → difluoro-(3-methyl-phenyl)-phosphine oxide (769-91-5) + C7H8FOP (127599-92-2) + C7H8F3P (127599-86-4)

Guidance literature:

With hydrogen fluoride; In benzene-d6; toluene; at -23.1 - 26.9 ℃; Thermodynamic data; ΔG₂₉₈(excit.), ΔH(excit.), ΔS(excit.);

upstream raw materials:

m-methylphenylphosphorus dichloride

C₇H₇F₂P

meta-bromotoluene