(2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate

Base Information

• Chemical Name: (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate
• CAS No.: 1391629-65-4
• Molecular Formula: C₂₈H₃₆N₂O₅
• Molecular Weight: 480.604
• Mol file: 1391629-65-4.mol

Synonyms:

Chemical Property of (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate

There total 4 articles about (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p,p'-dimethoxybenzhydrylamine (19293-62-0) → (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate (1391629-65-4)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 20 °C / Inert atmosphere; Sealed tube

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 4 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / dichloromethane / 6 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile; 1: |Petasis Reaction;

DOI:10.1021/jm4012643

Reference yield:

2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)-N-methoxy-N-methylacetamide (1391629-61-0) → (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate (1391629-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / 6 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm4012643

Reference yield:

2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)acetic acid (1391629-59-6) → (2S)-methyl 2-((2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)ethyl)amino)-4-methylpentanoate (1391629-65-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dichloromethane / 6 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/jm4012643

upstream raw materials:

C₂₁H₂₁NO₄

methyl (L)-leucinate hydrochloride

2-((bis(4-methoxyphenyl)methyl)amino)-2-(furan-2-yl)acetic acid

p,p'-dimethoxybenzhydrylamine

Downstream raw materials:

(3S,6R)-4-(5-(4-fluorophenyl)isoxazole-3-carbonyl)-6-(furan-2-yl)-3-isobutylpiperazin-2-one