C₂₀H₁₈ClN₃O₂S

Base Information

Chemical Name:C₂₀H₁₈ClN₃O₂S
CAS No.:1332336-74-9
Molecular Formula:C₂₀H₁₈ClN₃O₂S
Molecular Weight:399.901
Hs Code.:

C<sub>20</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>2</sub>S

Synonyms:

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Chemical Property of C₂₀H₁₈ClN₃O₂S

Chemical Property:

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Technology Process of C₂₀H₁₈ClN₃O₂S

There total 7 articles about C₂₀H₁₈ClN₃O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884495-38-9
6-chloro-4-methylnicotinaldehyde

: 1332336-74-9
C₂₀H₁₈ClN₃O₂S

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene

2: toluene-4-sulfonic acid / tetrahydrofuran

3: sodium hydride / N,N-dimethyl-formamide

4: ammonia / methanol / Reflux

5: sodium tetrahydroborate / ethanol; water

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.06.014

Reference yield:

: 1332336-58-9
C₁₃H₁₀ClNO

: 1332336-74-9
C₂₀H₁₈ClN₃O₂S

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / tetrahydrofuran

2: sodium hydride / N,N-dimethyl-formamide

3: ammonia / methanol / Reflux

4: sodium tetrahydroborate / ethanol; water

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With dmap; sodium tetrahydroborate; ammonia; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.014

Reference yield:

: 1332336-71-6
C₁₆H₁₅ClN₂O

: 1332336-74-9
C₂₀H₁₈ClN₃O₂S

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol; water

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.06.014