5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide

Base Information

• Chemical Name: 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide
• CAS No.: 1397877-50-7
• Molecular Formula: C₂₈H₂₂N₄O₅S
• Molecular Weight: 526.572
• Mol file: 1397877-50-7.mol

Synonyms:

Chemical Property of 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide

There total 3 articles about 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

4-chlorobenzaldehyde (104-88-1) + chloroacetic acid (79-11-8) + 6-Methyl-4-(4-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid phenylamide (182170-96-3) → 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide (1397877-50-7)

Guidance literature:

With sodium acetate; acetic anhydride; acetic acid; at 140 - 142 ℃; Reflux;

DOI:10.1007/s00044-012-0189-5

Reference yield:

N-phenylacetoacetamide (102-01-2,98624-45-4) → 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide (1397877-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; aluminum (III) chloride / methanol; water / Reflux

2: sodium acetate; acetic acid; acetic anhydride / 140 - 142 °C / Reflux

With hydrogenchloride; aluminum (III) chloride; sodium acetate; acetic anhydride; acetic acid; In methanol; water;

DOI:10.1007/s00044-012-0189-5

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 5-(4-nitrophenyl)-N-phenyl-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-(1,3)-thiazolo-(3,2-a)-pyrimidine-6-carboxamide (1397877-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; aluminum (III) chloride / methanol; water / Reflux

2: sodium acetate; acetic acid; acetic anhydride / 140 - 142 °C / Reflux

With hydrogenchloride; aluminum (III) chloride; sodium acetate; acetic anhydride; acetic acid; In methanol; water;

DOI:10.1007/s00044-012-0189-5

upstream raw materials:

N-phenylacetoacetamide

4-chlorobenzaldehyde

chloroacetic acid

6-Methyl-4-(4-nitro-phenyl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid phenylamide