2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

Base Information

Chemical Name:2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine
CAS No.:105686-76-8
Molecular Formula:C26H23NO3
Molecular Weight:397.474
Hs Code.:
DSSTox Substance ID:DTXSID20546612
Nikkaji Number:J3.424.102C
Wikidata:Q82424494

Synonyms:2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine;105686-76-8;DTXSID20546612

Suppliers and Price of 2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:397.16779360
Heavy Atom Count:30
Complexity:463

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=CC(=NC(=C2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

There total 4 articles about 2,6-Diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 127034-55-3,60246-63-1
3,4,5-trimethoxychalcone

: 16883-69-5
N-phenacylpyridinium bromide

: 105686-76-8
2,6-diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

Guidance literature:: With ammonium acetate; acetic acid; for 6h; Heating; other pyridinium ylides, other α,β-unsaturated ketones;

Reference yield: 55.0%

: 6-phenyl-4-(3,4,5-trimethoxyphenyl)pyridin-2-yl 4-methylbenzenesulfonate

: 98-80-6
phenylboronic acid

: 105686-76-8
2,6-diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

Guidance literature:: With palladium diacetate; sodium hydroxide; XPhos; In ethanol; water; butan-1-ol; at 100 ℃; for 12h; Sealed tube; Inert atmosphere;
DOI:10.1039/c5ob00545k

Reference yield:

: 127034-55-3
1-phenyl-3-(3,4,5-trimethoxyphenyl)-trans-prop-2-en-1-one

: 105686-76-8
2,6-diphenyl-4-(3,4,5-trimethoxyphenyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 3 h / Reflux

2: triethylamine; dmap / dichloromethane / 15 h / 25 °C

3: palladium diacetate; XPhos; sodium hydroxide / ethanol; butan-1-ol; water / 12 h / 100 °C / Sealed tube; Inert atmosphere

With dmap; ammonium acetate; palladium diacetate; triethylamine; sodium hydroxide; XPhos; In ethanol; dichloromethane; water; butan-1-ol; 1: |Michael Addition / 3: |Suzuki Coupling;
DOI:10.1039/c5ob00545k