Technology Process of 4-(2-(6-(2,6-dichloro-4-(furan-2-yl)phenyl)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)acetamido)adamantan-1-carboxamide
There total 4 articles about 4-(2-(6-(2,6-dichloro-4-(furan-2-yl)phenyl)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)acetamido)adamantan-1-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide; isopropyl alcohol;
at 20 ℃;
for 12h;
DOI:10.1016/j.bmcl.2019.126787
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / mineral oil; tetrahydrofuran / 3 h / 0 - 20 °C
2: lithium hydroxide monohydrate / trifluoroacetic acid; water / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dimethyl sulfoxide; isopropyl alcohol / 12 h / 20 °C
With
lithium hydroxide monohydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; dimethyl sulfoxide; isopropyl alcohol; trifluoroacetic acid; mineral oil;
DOI:10.1016/j.bmcl.2019.126787
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: sodium hydroxide / methanol; water / 12 h / 20 °C
3: sodium hydride / mineral oil; tetrahydrofuran / 3 h / 0 - 20 °C
4: lithium hydroxide monohydrate / trifluoroacetic acid; water / 5 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dimethyl sulfoxide; isopropyl alcohol / 12 h / 20 °C
With
lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; isopropyl alcohol; trifluoroacetic acid; mineral oil;
DOI:10.1016/j.bmcl.2019.126787
![4-aminotricyclo[3.3.1.13.7]decane-1-carboxamide hydrochloride](/Databaselist/images/loading.webp)
