2-(4-Phenylphenyl)piperidine

Base Information

• Chemical Name: 2-(4-Phenylphenyl)piperidine
• CAS No.: 383128-28-7
• Molecular Formula: C₁₇H₁₉N
• Molecular Weight: 237.345
• Mol file: 383128-28-7.mol

Synonyms:2-(4-phenylphenyl)piperidine;383128-28-7;2-[1,1'-BIPHENYL]-4-YLPIPERIDINE;2-([1,1'-Biphenyl]-4-yl)piperidine;2-(biphenyl-4-yl)piperidine;SCHEMBL3401744;BBL020737;MFCD02663603;STK893427;AKOS000201037;AKOS022060427;CS-0214707;N12734;EN300-1870896

Chemical Property of 2-(4-Phenylphenyl)piperidine

Chemical Property:

• Boiling Point: 379.8±31.0 °C(Predicted)
• PKA: 9.73±0.10(Predicted)
• Density: 1.023±0.06 g/cm3(Predicted)
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 237.151749610
• Heavy Atom Count: 18
• Complexity: 236

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCNC(C1)C2=CC=C(C=C2)C3=CC=CC=C3

Technology Process of 2-(4-Phenylphenyl)piperidine

There total 4 articles about 2-(4-Phenylphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(R)-2-(biphenyl-4-yl)piperidin-1-ol (1416428-67-5) → (2R)-2-biphenyl-4-ylpiperidine (1270091-09-2,383128-28-7)

Guidance literature:

With indium; hydroxylamine; ammonium chloride; zinc; enantioselective reaction; Reflux;

DOI:10.1021/ol303085q

Reference yield:

2-(biphenyl-4-yl)-5,6-dihydropyridin-1(2H)-ol → (2R)-2-biphenyl-4-ylpiperidine (1270091-09-2,383128-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; platinum(IV) oxide / methanol; ethanol / 1 h

2: hydroxylamine; ammonium chloride; zinc; indium / Reflux

With platinum(IV) oxide; indium; hydrogen; hydroxylamine; ammonium chloride; zinc; In methanol; ethanol;

DOI:10.1021/ol303085q

Reference yield:

6-biphenyl-4-yl-1,2,3,6-tetrahydropyridine → (2R)-2-biphenyl-4-ylpiperidine (1270091-09-2,383128-28-7) + (2S)-2-biphenyl-4-ylpiperidine (1269977-95-8,383128-28-7)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; ethanol; for 1h; Overall yield = 96 %; enantioselective reaction;

DOI:10.1021/ol303085q

upstream raw materials:

(R)-2-(biphenyl-4-yl)piperidin-1-ol