3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone

Base Information

• Chemical Name: 3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone
• CAS No.: 132331-23-8
• Molecular Formula: C₂₉H₂₄N₈O₄
• Molecular Weight: 548.561
• Mol file: 132331-23-8.mol

Synonyms:

Chemical Property of 3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone

There total 2 articles about 3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

diethyl 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylhydrazonomalonate (132331-10-3) + 2-hydrazino-3-(4-methylphenyl)quinazoline-4-(3H)-one (66679-65-0) → 3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone (132331-23-8)

Guidance literature:

With sulfuric acid; acetic acid; for 4h; Heating;

DOI:10.1002/ardp.19903231004

Reference yield:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) → 3-p-tolyl-2-<4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-hydrazono-3,5-dioxo-2H-pyrazolidin-1-yl>-4(3H)-quinazolinone (132331-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaNO₂, H₂SO₄, 2) aq.NaOAc / 1) H₂O, 2) EtOH, 3 h

2: 65 percent / glac.acetic acid, conc.H₂SO₄ / 4 h / Heating

With sulfuric acid; sodium acetate; acetic acid; sodium nitrite;

DOI:10.1002/ardp.19903231004

upstream raw materials:

diethyl 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylhydrazonomalonate

2-hydrazino-3-(4-methylphenyl)quinazoline-4-(3H)-one

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one