C₄₀H₅₇IO₈

Base Information

Chemical Name:C₄₀H₅₇IO₈
CAS No.:1404459-18-2
Molecular Formula:C₄₀H₅₇IO₈
Molecular Weight:792.792
Hs Code.:

C<sub>40</sub>H<sub>57</sub>IO<sub>8</sub>

Synonyms:

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Chemical Property of C₄₀H₅₇IO₈

Chemical Property:

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Technology Process of C₄₀H₅₇IO₈

There total 10 articles about C₄₀H₅₇IO₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₅₈O₈

: 1404459-18-2
C₄₀H₅₇IO₈

: C₄₀H₅₇IO₈

Guidance literature:: With N-iodo-succinimide; In dichloromethane; at -78 ℃; for 7.5h; Solvent; Overall yield = 87 %; Overall yield = 10.3 mg; Inert atmosphere;
DOI:10.1021/ol302751b

Reference yield:

: 1404459-03-5
(2S,3S,Z)-10-tert-butyldimethylsilyloxy-1-(4-methoxybenzyloxy)-2-methyl-7-(trimethylsilylmethylene)decane-3-ol

: 1404459-18-2
C₄₀H₅₇IO₈

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 14 h / 0 - 20 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-chloro-succinimide; tetrabutyl-ammonium chloride / dichloromethane / 19 h / pH 8.6

3.1: (-)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / -78 - 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; ethanol / tetrahydrofuran; water / 69 h / 20 °C

5.1: ozone; solvent red 19 / methanol / 0.02 h / -78 °C

5.2: 3 h / 20 °C / Inert atmosphere

5.3: 1 h / Inert atmosphere

6.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / 55 °C / Inert atmosphere; Molecular sieve

6.2: 0.5 h / 0 °C / Inert atmosphere; Molecular sieve

7.1: n-butyllithium; isopropylmagnesium bromide / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

7.2: 0.25 h / -78 °C / Inert atmosphere

7.3: 2 h / 0 °C / Inert atmosphere

8.1: N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; chromium dichloride; lithium chloride; manganese; C₁₀H₁₀O₄*NiCl₂; zirconocene dichloride / acetonitrile / 2 h / 20 °C / Inert atmosphere

9.1: N-iodo-succinimide / dichloromethane / 7.5 h / -78 °C / Inert atmosphere

With chromium dichloride; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; manganese; N-chloro-succinimide; N-iodo-succinimide; n-butyllithium; zirconocene dichloride; ethanol; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₁₀H₁₀O₄*NiCl₂; (-)-N-methylephedrine; tetrabutyl ammonium fluoride; tetrabutyl-ammonium chloride; isopropylmagnesium bromide; zinc trifluoromethanesulfonate; diisobutylaluminium hydride; ozone; triethylamine; lithium chloride; solvent red 19; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile; 8.1: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1021/ol302751b

Reference yield:

: C₂₃H₄₀O₄Si

: 1404459-18-2
C₄₀H₅₇IO₈

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; N-chloro-succinimide; tetrabutyl-ammonium chloride / dichloromethane / 19 h / pH 8.6

2.1: (-)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / -78 - 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride; ethanol / tetrahydrofuran; water / 69 h / 20 °C

4.1: ozone; solvent red 19 / methanol / 0.02 h / -78 °C

4.2: 3 h / 20 °C / Inert atmosphere

4.3: 1 h / Inert atmosphere

5.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / 55 °C / Inert atmosphere; Molecular sieve

5.2: 0.5 h / 0 °C / Inert atmosphere; Molecular sieve

6.1: n-butyllithium; isopropylmagnesium bromide / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

6.2: 0.25 h / -78 °C / Inert atmosphere

6.3: 2 h / 0 °C / Inert atmosphere

7.1: N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; chromium dichloride; lithium chloride; manganese; C₁₀H₁₀O₄*NiCl₂; zirconocene dichloride / acetonitrile / 2 h / 20 °C / Inert atmosphere

8.1: N-iodo-succinimide / dichloromethane / 7.5 h / -78 °C / Inert atmosphere

With chromium dichloride; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; manganese; N-chloro-succinimide; N-iodo-succinimide; n-butyllithium; zirconocene dichloride; ethanol; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; C₁₀H₁₀O₄*NiCl₂; (-)-N-methylephedrine; tetrabutyl-ammonium chloride; isopropylmagnesium bromide; zinc trifluoromethanesulfonate; diisobutylaluminium hydride; ozone; triethylamine; lithium chloride; solvent red 19; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile; 7.1: |Nozaki-Hiyama-Kishi Reaction;
DOI:10.1021/ol302751b