Technology Process of Benzoic acid (2S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-5-oxo-tetrahydro-furan-2-yl ester
There total 42 articles about Benzoic acid (2S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-5-oxo-tetrahydro-furan-2-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 16 steps
2: 1) O3, 2) Bun3P
3: 84 percent / Jones reagent
4: 60 percent / 1) LiHMDS / 1) THF, -78 deg C
5: 94 percent / LiAlH4
6: NEt3
7: 90 percent / Swern oxidation
8: 78 percent
9: 95 percent / DIBAL
10: 88 percent / NEt3
11: 90 percent / DDQ
12: 92 percent / Swern oxidation
13: 85 percent / NaClO2
14: 1) O3, 2) n-Bu3P
15: NEt3 / toluene / 0.5 h / Ambient temperature
16: dicyclohexyl-18-crown-O-6 / toluene / 0.33 h / Heating
With
perhydrodibenzo-18-crown-6; sodium chlorite; lithium aluminium tetrahydride; jones reagent; tributylphosphine; diisobutylaluminium hydride; ozone; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane;
In
toluene;
DOI:10.1016/S0040-4039(00)92712-6
- Guidance literature:
-
Multi-step reaction with 16 steps
2: 1) O3, 2) Bun3P
3: 84 percent / Jones reagent
4: 60 percent / 1) LiHMDS / 1) THF, -78 deg C
5: 94 percent / LiAlH4
6: NEt3
7: 90 percent / Swern oxidation
8: 78 percent
9: 95 percent / DIBAL
10: 88 percent / NEt3
11: 90 percent / DDQ
12: 92 percent / Swern oxidation
13: 85 percent / NaClO2
14: 1) O3, 2) n-Bu3P
15: NEt3 / toluene / 0.5 h / Ambient temperature
16: dicyclohexyl-18-crown-O-6 / toluene / 0.33 h / Heating
With
perhydrodibenzo-18-crown-6; sodium chlorite; lithium aluminium tetrahydride; jones reagent; tributylphosphine; diisobutylaluminium hydride; ozone; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane;
In
toluene;
DOI:10.1016/S0040-4039(00)92712-6
- Guidance literature:
-
Multi-step reaction with 15 steps
1: 1) O3, 2) Bun3P
2: 84 percent / Jones reagent
3: 60 percent / 1) LiHMDS / 1) THF, -78 deg C
4: 94 percent / LiAlH4
5: NEt3
6: 90 percent / Swern oxidation
7: 78 percent
8: 95 percent / DIBAL
9: 88 percent / NEt3
10: 90 percent / DDQ
11: 92 percent / Swern oxidation
12: 85 percent / NaClO2
13: 1) O3, 2) n-Bu3P
14: NEt3 / toluene / 0.5 h / Ambient temperature
15: dicyclohexyl-18-crown-O-6 / toluene / 0.33 h / Heating
With
perhydrodibenzo-18-crown-6; sodium chlorite; lithium aluminium tetrahydride; jones reagent; tributylphosphine; diisobutylaluminium hydride; ozone; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane;
In
toluene;
DOI:10.1016/S0040-4039(00)92712-6
