beta-(4,4-Difluoro-1-piperidinyl)-2-(trifluoromethyl)-5-pyrimidineethanamine

Base Information

• Chemical Name: beta-(4,4-Difluoro-1-piperidinyl)-2-(trifluoromethyl)-5-pyrimidineethanamine
• CAS No.: 1192569-99-5
• Molecular Formula: C₁₂H₁₅F₅N₄
• Molecular Weight: 310.27
• Mol file: 1192569-99-5.mol

Synonyms:

Chemical Property of beta-(4,4-Difluoro-1-piperidinyl)-2-(trifluoromethyl)-5-pyrimidineethanamine

Chemical Property:

• Density: 1.37±0.1 g/cm3 (20 oC 760 Torr)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of beta-(4,4-Difluoro-1-piperidinyl)-2-(trifluoromethyl)-5-pyrimidineethanamine

There total 4 articles about beta-(4,4-Difluoro-1-piperidinyl)-2-(trifluoromethyl)-5-pyrimidineethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C12H11F5N4 → 2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine (1192569-99-5)

Guidance literature:

With ammonia; hydrogen; In methanol; under 2327.23 Torr;

DOI:10.1016/j.bmcl.2016.08.029

Reference yield:

methyl-2-(trifluoromethyl)pyrimidine-5-carboxylate → 2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine (1192569-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane / -78 °C

2: acetic acid

3: ammonia; hydrogen / methanol / 2327.23 Torr

With ammonia; hydrogen; diisobutylaluminium hydride; acetic acid; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2016.08.029

Reference yield:

2-trifluoromethyl-5-pyrimidinecarboxaldehyde (304693-66-1) → 2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine (1192569-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: ammonia; hydrogen / methanol / 2327.23 Torr

With ammonia; hydrogen; acetic acid; In methanol;

DOI:10.1016/j.bmcl.2016.08.029

upstream raw materials:

2-trifluoromethyl-5-pyrimidinecarboxaldehyde

Refernces

• 1、 -. "Cyclic Amines". Paragraph 0095; 0096; 0119. . Retrieved 2014/05/07.