ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate
CAS No.:1361450-08-9
Molecular Formula:C₄₃H₆₃N₅O₅Si₂
Molecular Weight:786.175
Hs Code.:

ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Synonyms:

Suppliers and Price of ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

There total 11 articles about ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1361450-08-9
ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

1.2: -78 - 20 °C

2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 70 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: 20 °C

4.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

5.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

6.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

7.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 °C

9.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

10.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; ammonium cerium (IV) nitrate; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1361450-08-9
ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene-4-sulfonic acid / benzene / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

3.1: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 70 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 20 °C

5.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

6.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

7.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

8.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C / Inert atmosphere

9.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 °C

10.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

11.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; ammonium cerium (IV) nitrate; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile; benzene;

Reference yield:

: 147905-77-9
ethyl 1-methyl-4-oxo-1-cyclohexanecarboxylate

: 1361450-08-9
ethyl 4-(7-((bis(2-(trimethylsilyl)ethoxy)methyl)amino)-6-(1-ethoxyvinyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 20 °C

2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

4.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

5.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 °C

7.1: N-Bromosuccinimide / acetonitrile / 1 h / 20 °C

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; N-iodo-succinimide; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile;