5,8-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinoline

Base Information

• Chemical Name: 5,8-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinoline
• CAS No.: 131251-73-5
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.279
• DSSTox Substance ID: DTXSID901326032
• Nikkaji Number: J2.476.378A
• ChEMBL ID: CHEMBL1528427
• Mol file: 131251-73-5.mol

Synonyms:5,8-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinoline;131251-73-5;5,8-dimethoxy-1H,2H,3H-cyclopenta[b]quinoline;MLS001195555;CHEMBL1528427;DTXSID901326032;HMS2883B12;MFCD04124591;AKOS015992134;SMR000550316;SR-01000308990;12W-0817;SR-01000308990-1

Chemical Property of 5,8-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinoline

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 229.110278721
• Heavy Atom Count: 17
• Complexity: 271

Purity/Quality:

5,8-DIMETHOXY-2,3-DIHYDRO-1H-CYCLOPENTA[B]QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C2C=C3CCCC3=NC2=C(C=C1)OC

Technology Process of 5,8-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinoline

There total 5 articles about 5,8-dimethoxy-2,3-dihydro-1H-cyclopenta[b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-amino-3,6-dimethoxylbenzaldehyde (126522-16-5) + cyclopentanone (120-92-3) → 5,8-dimethoxycyclopentaquinoline (131251-73-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 48h; Heating;

DOI:10.1021/jo00004a029

Reference yield: 45.0%

C14H17NO3 → 5,8-dimethoxycyclopentaquinoline (131251-73-5)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2007.05.111

Reference yield: 8.0%

2-(2,5-dimethoxybenzylidene)cyclopentanone O-acetyloxime (1001592-13-7) → 5,8-dimethoxycyclopentaquinoline (131251-73-5)

Guidance literature:

In methanol; Irradiation;

DOI:10.1039/b711620a

upstream raw materials:

2-amino-3,6-dimethoxylbenzaldehyde

cyclopentanone

1-bromo-2-formylcyclopentene

2,5-dimethoxyaniline