Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester
• CAS No.: 90490-10-1
• Molecular Formula: C₁₆H₂₄O₁₀S₃
• Molecular Weight: 472.559
• Mol file: 90490-10-1.mol

Synonyms:

Chemical Property of Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester

There total 3 articles about Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(4S,5S)-5-Hydroxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-yl}-methanol (88948-50-9) → Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester (90490-10-1)

Guidance literature:

sulfonation;

DOI:10.1016/S0040-4039(01)91157-8

Reference yield:

β-p-tosylpropanal diethyl acetal (88948-48-5) → Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester (90490-10-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetalization

2: reduction

3: sulfonation

DOI:10.1016/S0040-4039(01)91157-8

Reference yield:

(4R,5R)-2-[2-(Toluene-4-sulfonyl)-ethyl]-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester (88948-49-6) → Methanesulfonic acid (4S,5S)-5-methanesulfonyloxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-ylmethyl ester (90490-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: reduction

2: sulfonation

DOI:10.1016/S0040-4039(01)91157-8

upstream raw materials:

{(4S,5S)-5-Hydroxymethyl-2-[2-(toluene-4-sulfonyl)-ethyl]-[1,3]dioxolan-4-yl}-methanol

β-p-tosylpropanal diethyl acetal

(4R,5R)-2-[2-(Toluene-4-sulfonyl)-ethyl]-[1,3]dioxolane-4,5-dicarboxylic acid diethyl ester

Downstream raw materials:

Acetic acid (S)-2-methanesulfonyloxy-1-[(2S,4R)-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-pyran-2-yl]-ethyl ester

Acetic acid (S)-1-[(2S,4R)-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-pyran-2-yl]-undecyl ester

Acetic acid (S)-2-phenyl-1-[(2S,4R)-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-pyran-2-yl]-ethyl ester

Acetic acid (S)-1-[(S)-6-hydroxy-4-(toluene-4-sulfonyl)-3,6-dihydro-2H-pyran-2-yl]-pentyl ester