(4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Base Information

• Chemical Name: (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one
• CAS No.: 135091-08-6
• Molecular Formula: C₄₂H₅₇N₃O₅S
• Molecular Weight: 715.998

Synonyms:

Chemical Property of (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

There total 24 articles about (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(2S,6S)-1-{3-[(4-Amino-butyl)-(toluene-4-sulfonyl)-amino]-propyl}-6-((1S,2R)-1,2-bis-benzyloxy-heptyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-acetic acid → (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one (135091-08-6)

Guidance literature:

With dmap; 2-chloro-1-methyl-pyridinium iodide; In dichloromethane; Yield given;

DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

Tetrakis(benzyloxy)titanium (19803-37-3) → (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one (135091-08-6)

Guidance literature:

Multi-step reaction with 22 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

9: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂ / -60 °C

10: tetrahydrofuran

11: 93 percent / CSA

12: 86 percent / Na, C₁₀H₈ / tetrahydrofuran

13: 94 percent / K₂CO₃ / benzene; toluene; H₂O

14: 94 percent / LAH / tetrahydrofuran / Heating

15: 95 percent / K₂CO₃ / dimethylformamide

16: NH₂NH₂ / ethanol

17: CH₂Cl₂

18: TsOH/acetone

19: K₂CO₃/MeOH

20: 1.) NaOCl₂ / 1.) 2-methyl-2-butene, t-BuOH, 2.) Et₂O

21: Ba(OH)2 / methanol; H₂O

22: 2-chloro-1-methylpyridinium iodide, DMAP / CH₂Cl₂

With methanol; dmap; barium dihydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; naphthalene; camphor-10-sulfonic acid; 2-chloro-1-methyl-pyridinium iodide; sodium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; acetone; hydrazine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

[(2S,3S)-3-pentyloxiran-2-yl]methanol (89461-51-8) → (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one (135091-08-6)

Guidance literature:

Multi-step reaction with 22 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

9: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂ / -60 °C

10: tetrahydrofuran

11: 93 percent / CSA

12: 86 percent / Na, C₁₀H₈ / tetrahydrofuran

13: 94 percent / K₂CO₃ / benzene; toluene; H₂O

14: 94 percent / LAH / tetrahydrofuran / Heating

15: 95 percent / K₂CO₃ / dimethylformamide

16: NH₂NH₂ / ethanol

17: CH₂Cl₂

18: TsOH/acetone

19: K₂CO₃/MeOH

20: 1.) NaOCl₂ / 1.) 2-methyl-2-butene, t-BuOH, 2.) Et₂O

21: Ba(OH)2 / methanol; H₂O

22: 2-chloro-1-methylpyridinium iodide, DMAP / CH₂Cl₂

With methanol; dmap; barium dihydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; naphthalene; camphor-10-sulfonic acid; 2-chloro-1-methyl-pyridinium iodide; sodium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; acetone; hydrazine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1016/S0040-4039(00)74295-X

upstream raw materials:

Tetrakis(benzyloxy)titanium

[(2S,3S)-3-pentyloxiran-2-yl]methanol

benzyl chloride

(2S,3R)-2,3-Bis-benzyloxy-octan-1-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 135091-08-6 (4S,15aS)-4-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send