(S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester
CAS No.:871815-65-5
Molecular Formula:C₃₄H₄₈Cl₂N₄O₈
Molecular Weight:711.683
Hs Code.:

(S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

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Chemical Property of (S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

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Technology Process of (S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

There total 4 articles about (S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871815-60-0
[5-tert-butoxycarbonylamino-5-(methoxy-methyl-carbamoyl)-pentyl]-carbamic acid 2-chloro-benzyl ester

: 871815-65-5
(S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: NaBH₃CN; CH₃COOH / methanol

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2005.09.157

Reference yield:

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: 871815-65-5
(S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Acid hydrolysis

2: NaBH₃CN; CH₃COOH / methanol

With sodium cyanoborohydride; acetic acid; In methanol;
DOI:10.1016/j.tetlet.2005.09.157

Reference yield:

: 57096-11-4
N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-D-lysine

: 871815-65-5
(S)-2-[(R)-2-tert-Butoxycarbonylamino-6-(2-chloro-benzyloxycarbonylamino)-hexylamino]-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HBTU; DIEA; HCl / dimethylformamide

2: LiAlH₄ / tetrahydrofuran

3: NaBH₃CN; CH₃COOH / methanol

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2005.09.157