Technology Process of 1α,2,3,4,4a,9,10,10aα-octahydro-7-methoxy-1α-methyl-4aβ-(3-phenyl-2-thiapropyl)-2-phenanthrone 2-(ethylene acetal)
There total 7 articles about 1α,2,3,4,4a,9,10,10aα-octahydro-7-methoxy-1α-methyl-4aβ-(3-phenyl-2-thiapropyl)-2-phenanthrone 2-(ethylene acetal) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 84 percent / K2CO3 / methanol / 72 h / Ambient temperature
2: 82 percent / H2 / 10percent Pd/C / ethanol; pyridine / 72 h
3: 80 percent / p-toluenesulfonic acid / benzene / 48 h / Heating
4: 94 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
5: Et3N / CH2Cl2 / 1.5 h / -78 °C
6: LiCl, N-methylpyrrolidinone (NMP) / -78 - 20 °C
7: 1.) NaH, N-methylpyrrolidinone (NMP) / 1.) RT, 1 h, 2.) 55-60 deg C, 9 d
With
1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00380a020
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / H2 / 10percent Pd/C / ethanol; pyridine / 72 h
2: 80 percent / p-toluenesulfonic acid / benzene / 48 h / Heating
3: 94 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
4: Et3N / CH2Cl2 / 1.5 h / -78 °C
5: LiCl, N-methylpyrrolidinone (NMP) / -78 - 20 °C
6: 1.) NaH, N-methylpyrrolidinone (NMP) / 1.) RT, 1 h, 2.) 55-60 deg C, 9 d
With
1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; hydrogen; sodium hydride; toluene-4-sulfonic acid; triethylamine; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00380a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 1.5 h / -78 °C
2: LiCl, N-methylpyrrolidinone (NMP) / -78 - 20 °C
3: 1.) NaH, N-methylpyrrolidinone (NMP) / 1.) RT, 1 h, 2.) 55-60 deg C, 9 d
With
1-methyl-pyrrolidin-2-one; sodium hydride; triethylamine; lithium chloride;
In
dichloromethane;
DOI:10.1021/jo00380a020
