(1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol

Base Information

• Chemical Name: (1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol
• CAS No.: 1308314-78-4
• Molecular Formula: C₄₁H₅₉NO₇Si₂
• Molecular Weight: 734.093

Synonyms:

Chemical Property of (1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol

There total 10 articles about (1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C42H61NO6Si2 → (+)-(1S,3'R,4'S.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol (1308315-01-6) + (1R,3'R,4'S.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol (1308314-78-4)

Guidance literature:

In dichloromethane; acetone; at -78 - 20 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ja201249c

Reference yield:

(2-bromo-5-nitro-phenyl)methanol (332883-48-4) → (+)-(1S,3'R,4'S.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol (1308315-01-6) + (1R,3'R,4'S.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol (1308314-78-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 20 h / Reflux; Inert atmosphere

4.1: diisobutylaluminium hydride / toluene / -78 - 20 °C / Inert atmosphere

5.1: dmap; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Reflux; Darkness; Inert atmosphere

7.1: methanol; potassium carbonate / tetrahydrofuran

8.1: 3,3-dimethyldioxirane / methanol; dichloromethane; acetone / 0.17 h / -78 °C / Inert atmosphere

9.1: methanol / dichloromethane; acetone / -63 - 20 °C / Inert atmosphere

With methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; 3,3-dimethyldioxirane; sodium hydride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; triethylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination / 6.1: Stille coupling;

DOI:10.1021/ja201249c

Reference yield:

3-(2-bromo-5-nitrophenyl)propyl acetate → (+)-(1S,3'R,4'S.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol (1308315-01-6) + (1R,3'R,4'S.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol (1308314-78-4)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Reflux; Darkness; Inert atmosphere

2: methanol; potassium carbonate / tetrahydrofuran

3: 3,3-dimethyldioxirane / methanol; dichloromethane; acetone / 0.17 h / -78 °C / Inert atmosphere

4: methanol / dichloromethane; acetone / -63 - 20 °C / Inert atmosphere

With methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 3,3-dimethyldioxirane; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; 1: Stille coupling;

DOI:10.1021/ja201249c

upstream raw materials:

(2-bromo-5-nitro-phenyl)methanol

(-)-3-(2-((2R,4S)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-nitrophenyl)propan-1-ol

2-bromo-5-nitrobenzaldehyde

2-bromo-5-nitrobenzoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1308314-78-4 (1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-nitro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send