C₃₇H₂₈ClN₃O₄

Base Information

• Chemical Name: C₃₇H₂₈ClN₃O₄
• CAS No.: 936566-19-7
• Molecular Formula: C₃₇H₂₈ClN₃O₄
• Molecular Weight: 614.1
• Mol file: 936566-19-7.mol

Synonyms:

Chemical Property of C₃₇H₂₈ClN₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₂₈ClN₃O₄

There total 6 articles about C₃₇H₂₈ClN₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

C29H24BrClN2O2 (936566-18-6) + potassium phtalimide (1074-82-4) → C37H28ClN3O4 (936566-19-7)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2007.01.043

Reference yield:

(E)-1-(3-chlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one → C37H28ClN3O4 (936566-19-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 65 percent / LiOH / tetrahydrofuran / 2 h / 25 °C

2.1: 73 percent / ammonium ferric sulphate dodecahydrate; NH₄OAC; AcOH / 3 h / Heating

3.1: BBr₃ / CH₂Cl₂ / 2 h / 25 °C

3.2: 61 percent / H₂O / CH₂Cl₂ / 1 h

4.1: K₂CO₃ / acetone / 0.5 h / Heating

4.2: 58 percent / acetone / Heating

5.1: 59 percent / dimethylsulfoxide / 0.5 h / 90 °C

With lithium hydroxide; ammonium iron(III) sulfate dodecahydrate; ammonium acetate; boron tribromide; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Michael addition;

DOI:10.1016/j.bmcl.2007.01.043

Reference yield:

C26H19ClN2O2 (936566-30-2) → C37H28ClN3O4 (936566-19-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BBr₃ / CH₂Cl₂ / 2 h / 25 °C

1.2: 61 percent / H₂O / CH₂Cl₂ / 1 h

2.1: K₂CO₃ / acetone / 0.5 h / Heating

2.2: 58 percent / acetone / Heating

3.1: 59 percent / dimethylsulfoxide / 0.5 h / 90 °C

With boron tribromide; potassium carbonate; In dichloromethane; dimethyl sulfoxide; acetone;

DOI:10.1016/j.bmcl.2007.01.043

upstream raw materials:

C₂₉H₂₄BrClN₂O₂

potassium phtalimide

C₂₆H₁₉ClN₂O₂

C₂₅H₁₇ClN₂O₂