Carbamic acid, [2-amino-6-[4-(cyclohexylmethylamino)-4-oxobutoxy]-3(4H)-quinazolinyl] -, methyl ester, monohydrobromide

Base Information

• Chemical Name: Carbamic acid, [2-amino-6-[4-(cyclohexylmethylamino)-4-oxobutoxy]-3(4H)-quinazolinyl] -, methyl ester, monohydrobromide
• CAS No.: 105728-58-3
• Molecular Formula: C21H31N5O4.BrH
• Molecular Weight: 498.42
• Mol file: 105728-58-3.mol

Synonyms:

Chemical Property of Carbamic acid, [2-amino-6-[4-(cyclohexylmethylamino)-4-oxobutoxy]-3(4H)-quinazolinyl] -, methyl ester, monohydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [2-amino-6-[4-(cyclohexylmethylamino)-4-oxobutoxy]-3(4H)-quinazolinyl] -, methyl ester, monohydrobromide

There total 3 articles about Carbamic acid, [2-amino-6-[4-(cyclohexylmethylamino)-4-oxobutoxy]-3(4H)-quinazolinyl] -, methyl ester, monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-[1-{5-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-phenyl}-meth-(E)-ylidene]-hydrazinecarboxylic acid methyl ester (105728-60-7) → {2-Amino-6-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-4H-quinazolin-3-yl}-carbamic acid methyl ester; hydrobromide (105728-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00385a012

Reference yield:

N-Cyclohexyl-N-methyl-4-(3-formyl-4-nitrophenyl)-oxybutyramide (94193-38-1) → {2-Amino-6-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-4H-quinazolin-3-yl}-carbamic acid methyl ester; hydrobromide (105728-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / aq. HCl / methanol / Heating

2: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: ethanol

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00385a012

Reference yield:

bromocyane (506-68-3) + N'-{2-Amino-5-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-benzyl}-hydrazinecarboxylic acid methyl ester → {2-Amino-6-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-4H-quinazolin-3-yl}-carbamic acid methyl ester; hydrobromide (105728-58-3)

Guidance literature:

In ethanol;

DOI:10.1021/jm00385a012

upstream raw materials:

bromocyane

N'-[1-{5-[3-(Cyclohexyl-methyl-carbamoyl)-propoxy]-2-nitro-phenyl}-meth-(E)-ylidene]-hydrazinecarboxylic acid methyl ester

N-Cyclohexyl-N-methyl-4-(3-formyl-4-nitrophenyl)-oxybutyramide

Downstream raw materials:

N-cyclohexyl-N-methyl-4-<(1,2,3,5-tetrahydro-2-oxotriazo<3,2-b>quinazolin-7-yl)oxy>butyramide

Refernces