C₁₉H₁₅Cl₂N₃O₃

Base Information

• Chemical Name: C₁₉H₁₅Cl₂N₃O₃
• CAS No.: 1415407-15-6
• Molecular Formula: C₁₉H₁₅Cl₂N₃O₃
• Molecular Weight: 404.252
• Mol file: 1415407-15-6.mol

Synonyms:

Chemical Property of C₁₉H₁₅Cl₂N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₅Cl₂N₃O₃

There total 4 articles about C₁₉H₁₅Cl₂N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C11H5Cl3N2O2 + 2-methoxy-N-methylaniline (10541-78-3) → C19H15Cl2N3O3 (1415407-15-6)

Guidance literature:

With triethylamine; at 20 ℃; for 3h;

DOI:10.1021/jm301071h

Reference yield:

ethyl 4-hydroxypyrimidine-5-carboxylate (4786-52-1,71133-20-5) → C19H15Cl2N3O3 (1415407-15-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 1 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C

4.1: thionyl chloride / 1 h / Reflux

5.1: triethylamine / 3 h / 20 °C

With thionyl chloride; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm301071h

Reference yield:

ethyl 4-(2,5-dichlorophenoxy)pyrimidine-5-carboxylate (1315469-71-6) → C19H15Cl2N3O3 (1415407-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C

2: thionyl chloride / 1 h / Reflux

3: triethylamine / 3 h / 20 °C

With thionyl chloride; water; triethylamine; sodium hydroxide; In ethanol;

DOI:10.1021/jm301071h

upstream raw materials:

2-methoxy-N-methylaniline

ethyl 4-hydroxypyrimidine-5-carboxylate

ethyl 4-chloropyrimidine-5-carboxylate

ethyl 4-(2,5-dichlorophenoxy)pyrimidine-5-carboxylate

Refernces