(rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane

Base Information

• Chemical Name: (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane
• CAS No.: 127641-88-7
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.216
• Mol file: 127641-88-7.mol

Synonyms:

Chemical Property of (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane

There total 3 articles about (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,2-benzo-1,3-cycloheptadiene (7125-62-4) → (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane (4443-71-4,127641-88-7,127641-89-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃;

Reference yield:

1-benzosuberol (35550-94-8,65915-63-1,79416-49-2,138381-73-4) → (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane (4443-71-4,127641-88-7,127641-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / p-TsOH / benzene / 1 h / Heating

2: 75 percent / m-chloroperbenzoic acid / CHCl₃ / 0 °C

With 3-chloro-benzenecarboperoxoic acid; toluene-4-sulfonic acid; In chloroform; benzene;

Reference yield:

1-Benzosuberone (826-73-3) → (rac)-5,6-epoxy-6,7,8,9-tetrahydro-5-benzocycloheptane (4443-71-4,127641-88-7,127641-89-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 - 20 ℃; for 12h;

DOI:10.1002/anie.201406645

upstream raw materials:

1,2-benzo-1,3-cycloheptadiene

1-benzosuberol

1-Benzosuberone

Downstream raw materials:

1-methoxy-2-tosyloxy-benzosuberan