(6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester
• CAS No.: 81035-29-2
• Molecular Formula: C₂₈H₄₀N₇O₁₀P
• Molecular Weight: 665.64

Synonyms:

Chemical Property of (6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester

Chemical Property:

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Useful:

Technology Process of (6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester

There total 2 articles about (6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloropurine riboside 5'-monophosphate (5843-59-4,59126-39-5) → (6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester (81035-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O / 6 h / 80 °C

2: aq. NaHCO₃ / 2-methoxy-ethanol / 8 h / Ambient temperature

With sodium hydrogencarbonate; In 2-methoxy-ethanol; water;

DOI:10.1021/jm00346a009

Reference yield:

Phosphoric acid mono-{(2R,3S,4R,5R)-5-[6-(3-amino-propylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl} ester (78261-66-2) + 7-Benzyloxycarbonylamino-heptanoic acid 2,5-dioxo-pyrrolidin-1-yl ester (108257-17-6) → (6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester (81035-29-2)

Guidance literature:

With sodium hydrogencarbonate; In 2-methoxy-ethanol; for 8h; Ambient temperature;

DOI:10.1021/jm00346a009

Reference yield:

(6-{3-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-propylcarbamoyl}-hexyl)-carbamic acid benzyl ester (81035-29-2) → C28H38N7O16P3(4-)*4Na(1+)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jm00346a009

upstream raw materials:

Phosphoric acid mono-{(2R,3S,4R,5R)-5-[6-(3-amino-propylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl} ester

7-Benzyloxycarbonylamino-heptanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

6-chloropurine riboside 5'-monophosphate

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