Technology Process of (RS,SR)-γ-hydroxy-β-methyl-γ-<4-(methylsulfonyl)phenyl>butanoic acid lactone
There total 5 articles about (RS,SR)-γ-hydroxy-β-methyl-γ-<4-(methylsulfonyl)phenyl>butanoic acid lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: AlCl3 / CH2Cl2 / 1 h / Ambient temperature
2: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 1 h, 2.) toluene THF, -78 deg C, 1 h
3: 100 percent / mCPBA / Ambient temperature
4: 2N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature
5: DIBAL-H / toluene; tetrahydrofuran / 3 h / -78 °C
6: TFA / CH2Cl2 / 2 h / Ambient temperature
With
sodium hydroxide; aluminium trichloride; potassium hexamethylsilazane; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo00378a035
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 1 h, 2.) toluene THF, -78 deg C, 1 h
2: 100 percent / mCPBA / Ambient temperature
3: 2N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature
4: DIBAL-H / toluene; tetrahydrofuran / 3 h / -78 °C
5: TFA / CH2Cl2 / 2 h / Ambient temperature
With
sodium hydroxide; potassium hexamethylsilazane; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo00378a035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / mCPBA / Ambient temperature
2: 2N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature
3: DIBAL-H / toluene; tetrahydrofuran / 3 h / -78 °C
4: TFA / CH2Cl2 / 2 h / Ambient temperature
With
sodium hydroxide; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo00378a035
