(+)-Phenazocine

Base Information

• Chemical Name: (+)-Phenazocine
• CAS No.: 64023-93-4
• Molecular Formula: C₂₂H₂₇NO
• Molecular Weight: 321.462
• UNII: 2G2E2LC4CD
• Wikidata: Q27254697
• NCI Thesaurus Code: C96728
• Metabolomics Workbench ID: 143560
• ChEMBL ID: CHEMBL94350

Synonyms:Hydrobromide, Phenazocine;Narphen;Phenazocine;Phenazocine Hydrobromide;Phenbenzorphan;Phenethylazocine

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Chemical Property of (+)-Phenazocine

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 321.209264485
• Heavy Atom Count: 24
• Complexity: 432

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1C2CC3=C(C1(CCN2CCC4=CC=CC=C4)C)C=C(C=C3)O
• Isomeric SMILES: C[C@@H]1[C@@H]2CC3=C([C@]1(CCN2CCC4=CC=CC=C4)C)C=C(C=C3)O

Technology Process of (+)-Phenazocine

There total 4 articles about (+)-Phenazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) → (+/-)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol (127-35-5,56942-74-6,58073-76-0,58640-87-2,64023-93-4,100100-58-1)

Guidance literature:

Erwaermen des Reaktionsprodukts mit Bromcyan in Chloroform,Erhitzen Rueckstandes mit wss.Salzsaeure, Behandeln mit wss.Methanol, Kaliumcarbonat und Phenylacetylchlorid und Erwaermen mit LiAlH₄;

DOI:10.1021/jo01092a012

Reference yield:

acetic anhydride (108-24-7) + (+)-3,6,11syn-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol (3734-52-9,21286-57-7,21286-60-2,25144-79-0,25145-09-9,58640-79-2,64023-94-5,67009-58-9,69831-04-5,36402-80-9,75257-89-5,1509-00-8) → (+)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol (127-35-5,56942-74-6,58073-76-0,58640-87-2,64023-93-4,100100-58-1)

Guidance literature:

Erwaermen des Reaktionsprodukts mit Bromcyan CHCl₃, Erhitzen mit wss.Salzsaeure, Behandeln mit wss.Methanol, Kaliumcarbonat und Phenylacetylchlorid und Erwaermen mit LiAlH₄;

DOI:10.1021/jo01092a012

Reference yield:

acetic anhydride (108-24-7) → (-)-6,11syn-dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol (127-35-5,56942-74-6,58073-76-0,58640-87-2,64023-93-4,100100-58-1)

Guidance literature:

Erwaermen des Reaktionsprodukts mit Bromcyan in Chloroform, Erhitzen Rueckstandes mit wss.Salzsaeure, Behandeln mit wss.Methanol, Kaliumcarbonat und Phenylacetalchlorid und Erwaermen mit LiAlH₄;

DOI:10.1021/jo01092a012

upstream raw materials:

acetic anhydride

1-phenyl-2-bromoethane

(+)-cis-N-Normetazocine

(+)-3,6,11syn-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benz[d]azocin-8-ol