Technology Process of (2R,6R,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-2,6,8-trimethyl-5-oxo-nonanoic acid methyl ester
There total 17 articles about (2R,6R,8R)-9-(tert-Butyl-diphenyl-silanyloxy)-2,6,8-trimethyl-5-oxo-nonanoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) Et3N, DMAP / 1)CH2Cl2
2: 1)LDA / 1) THF, 2) HMPA
3: Claisen rearrangement
4: KOH
5: 1) OsO4, 2) camphorsulfonic acid / 1) pyridine, 2) benzene
6: PCC, NaOAc / CH2Cl2
7: aluminum amalgam / tetrahydrofuran; aq. ethanol
8: diethyl ether
With
dmap; potassium hydroxide; osmium(VIII) oxide; aluminium amalgam; camphor-10-sulfonic acid; sodium acetate; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo01305a044
- Guidance literature:
-
Multi-step reaction with 13 steps
2: 81 percent / LDA / tetrahydrofuran
3: 84 percent / 10percent HCl / tetrahydrofuran
4: 1) o-NO2C6H4SeCN, Bu3P, 2) 50percent H2O2 / 1)THF
5: 94 percent / LiAlH4
6: 1) Et3N, DMAP / 1)CH2Cl2
7: 1)LDA / 1) THF, 2) HMPA
8: Claisen rearrangement
9: KOH
10: 1) OsO4, 2) camphorsulfonic acid / 1) pyridine, 2) benzene
11: PCC, NaOAc / CH2Cl2
12: aluminum amalgam / tetrahydrofuran; aq. ethanol
13: diethyl ether
With
hydrogenchloride; dmap; potassium hydroxide; osmium(VIII) oxide; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; tributylphosphine; aluminium amalgam; camphor-10-sulfonic acid; dihydrogen peroxide; sodium acetate; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo01305a044
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1) o-NO2C6H4SeCN, Bu3P, 2) 50percent H2O2 / 1)THF
2: 94 percent / LiAlH4
3: 1) Et3N, DMAP / 1)CH2Cl2
4: 1)LDA / 1) THF, 2) HMPA
5: Claisen rearrangement
6: KOH
7: 1) OsO4, 2) camphorsulfonic acid / 1) pyridine, 2) benzene
8: PCC, NaOAc / CH2Cl2
9: aluminum amalgam / tetrahydrofuran; aq. ethanol
10: diethyl ether
With
dmap; potassium hydroxide; osmium(VIII) oxide; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; tributylphosphine; aluminium amalgam; camphor-10-sulfonic acid; dihydrogen peroxide; sodium acetate; triethylamine; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo01305a044
