Technology Process of tert-butyl ((1S,4R,E)-4-hydroxy-1,5-diphenylpent-2-en-1-yl)carbamate
There total 4 articles about tert-butyl ((1S,4R,E)-4-hydroxy-1,5-diphenylpent-2-en-1-yl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: L-proline / tetrahydrofuran / 22 h / -30 °C
2: chromium dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0 - 20 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.42 h / -30 °C
4: phosphorous acid trimethyl ester; methanol / 2 h / 40 °C
With
chromium dichloride; methanol; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; L-proline; phosphorous acid trimethyl ester;
In
tetrahydrofuran; dichloromethane;
1: |Mannich Aminomethylation / 2: |Takai-Utimoto Olefination;
DOI:10.1039/c3cc47827k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: chromium dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0 - 20 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.42 h / -30 °C
3: phosphorous acid trimethyl ester; methanol / 2 h / 40 °C
With
chromium dichloride; methanol; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; phosphorous acid trimethyl ester;
In
tetrahydrofuran; dichloromethane;
1: |Takai-Utimoto Olefination;
DOI:10.1039/c3cc47827k
- Guidance literature:
-
With
methanol; phosphorous acid trimethyl ester;
at 40 ℃;
for 2h;
stereoselective reaction;
DOI:10.1039/c3cc47827k
