Wdmzlttvvydahh-uhfffaoysa-N

Base Information

Chemical Name:Wdmzlttvvydahh-uhfffaoysa-N
CAS No.:105743-54-2
Molecular Formula:C₁₀H₁₁F₂NO₂
Molecular Weight:215.2
Hs Code.:
DSSTox Substance ID:DTXSID001291088

Synonyms:SCHEMBL1274883;WDMZLTTVVYDAHH-UHFFFAOYSA-N;DTXSID001291088;D-Phenylalanine, alpha-(difluoromethyl)-;2-amino-2-benzyl-3,3-difluoropropanoic acid;105743-54-2;InChI=1/C10H11F2NO2/c11-8(12)10(13,9(14)15)6-7-4-2-1-3-5-7/h1-5,8H,6,13H2,(H,14,15

Suppliers and Price of Wdmzlttvvydahh-uhfffaoysa-N

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Wdmzlttvvydahh-uhfffaoysa-N

Chemical Property:

XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:215.07578492
Heavy Atom Count:15
Complexity:230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(C(F)F)(C(=O)O)N

Technology Process of Wdmzlttvvydahh-uhfffaoysa-N

There total 9 articles about Wdmzlttvvydahh-uhfffaoysa-N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 182493-38-5
N-(benzyloxycarbonyl)-α-(difluoromethyl)phenylalanine

: 70471-32-8,105743-54-2
2-(difluoromethyl)phenylalanine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 14h;
DOI:10.1021/jo9608331

Reference yield:

: 174364-23-9
2-Benzyl-2-benzyloxycarbonylamino-3-bromo-3,3-difluoro-propionic acid methyl ester

: 70471-32-8,105743-54-2
2-(difluoromethyl)phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / n-Bu₃SnH / tetrahydrofuran / Heating

2: 91 percent / aq. KOH/MeOH / diethyl ether / 12 h

3: 89 percent / H₂ / Pd/C / methanol / 14 h

With methanol; potassium hydroxide; hydrogen; tri-n-butyl-tin hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo9608331

Reference yield:

: 182493-29-4
2-Benzyl-2-benzyloxycarbonylamino-3,3-difluoro-propionic acid methyl ester

: 70471-32-8,105743-54-2
2-(difluoromethyl)phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. KOH/MeOH / diethyl ether / 12 h

2: 89 percent / H₂ / Pd/C / methanol / 14 h

With methanol; potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1021/jo9608331