(2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Base Information

Chemical Name:(2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride
CAS No.:127258-40-6
Molecular Formula:C₂₁H₂₇N₇O₄*ClH
Molecular Weight:477.951
Hs Code.:

(2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Synonyms:

Suppliers and Price of (2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

There total 6 articles about (2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127258-41-7
(3aS,4S,6R,6aR)-6-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

: 127258-40-6
(2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Guidance literature:: With hydrogenchloride; at 65 ℃; for 1h; Yield given;
DOI:10.1021/jm00169a015

Reference yield:

: 24639-06-3
((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

: 127258-40-6
(2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / aq. KOH, KMnO₄ / H₂O / 72 h

2: SOCl₂ / dimethylformamide / 2 h / 50 °C

3: CH₂Cl₂ / 1 h / Ambient temperature

4: 3 h / 130 °C

5: 1 N HCl / 1 h / 65 °C

With hydrogenchloride; potassium hydroxide; potassium permanganate; thionyl chloride; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00169a015

Reference yield:

: (3aS,4S,6R,6aR)-6-(6-Amino-2-chloro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carbonyl chloride

: 127258-40-6
(2S,3S,4R,5R)-5-[6-Amino-2-(methyl-phenethyl-amino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-carboxylic acid ethylamide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 1 h / Ambient temperature

2: 3 h / 130 °C

3: 1 N HCl / 1 h / 65 °C

With hydrogenchloride; In dichloromethane;
DOI:10.1021/jm00169a015