(+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine

Base Information

• Chemical Name: (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine
• CAS No.: 128631-60-7
• Molecular Formula: C₁₇H₂₁N₅O₃
• Molecular Weight: 343.385
• Mol file: 128631-60-7.mol

Synonyms:

Chemical Property of (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine

There total 7 articles about (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(+/-)-2-amino-6-chloro-9-<5-(benzyloxy)-3-hydroxypent-1-yl>-9H-purine (128631-59-4) → (+/-)-9-(3,5-dihydroxypent-1-yl)guanine (128631-61-8) + (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine (128631-60-7)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1021/jm00171a022

Reference yield:

4-benzyloxybut-1-ene (70388-33-9) → (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine (128631-60-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 87 percent / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

2: 95 percent / Et₂AlCl / hexane / Ambient temperature

3: 58 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

4: 72 percent / Et₃N / butan-1-ol / 48 h / 100 °C

6: 35 percent / 1 N HCl / 6 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; diethylaluminium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; hexane; dichloromethane; butan-1-ol;

DOI:10.1021/jm00171a022

Reference yield:

(+/-)-1-amino-5-(benzyloxy)pentan-3-ol (128631-53-8) → (+/-)-9-<5-(benzyloxy)-3-hydroxypent-1-yl>guanine (128631-60-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / Et₃N / butan-1-ol / 48 h / 100 °C

3: 35 percent / 1 N HCl / 6 h / Heating

With hydrogenchloride; triethylamine; In butan-1-ol;

DOI:10.1021/jm00171a022

upstream raw materials:

(+/-)-2-amino-6-chloro-9-<5-(benzyloxy)-3-hydroxypent-1-yl>-9H-purine

4-benzyloxybut-1-ene

(+/-)-1-amino-5-(benzyloxy)pentan-3-ol

(+/-)-5-(benzyloxy)-3-(trimethylsiloxy)pentanenitrile

Downstream raw materials:

(+/-)-9-(3,5-dihydroxypent-1-yl)guanine