Technology Process of threo-6-<1-(Benzyloxy)-2-methylpropyl>-5,6-dihydro-4-methoxy-2H-pyran-2-one
There total 12 articles about threo-6-<1-(Benzyloxy)-2-methylpropyl>-5,6-dihydro-4-methoxy-2H-pyran-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) reflux, 12-20 h
2: 1.) ozone, 2.) dimethyl sulfide / 1.) dichloromethane, -78 deg C, 2.) -78 deg C to room temperature, 2-3 h, then room temperature, 12 h
3: MgBr2*OEt2 / CH2Cl2 / Ambient temperature; 18-24 h
With
dimethylsulfide; sodium hydride; ozone; magnesium bromide;
In
dichloromethane;
DOI:10.1021/jo00304a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) reflux, 12-20 h
2: 1.) ozone, 2.) dimethyl sulfide / 1.) dichloromethane, -78 deg C, 2.) -78 deg C to room temperature, 2-3 h, then room temperature, 12 h
3: MgBr2*OEt2 / CH2Cl2 / Ambient temperature; 18-24 h
With
dimethylsulfide; sodium hydride; ozone; magnesium bromide;
In
dichloromethane;
DOI:10.1021/jo00304a018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 10 min, then warmed to room temperature over 1 h
2: MgBr2*OEt2 / CH2Cl2 / Ambient temperature; 18-24 h
With
magnesium bromide; lithium diisopropyl amide;
In
dichloromethane;
DOI:10.1021/jo00304a018
