4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite

Base Information

• Chemical Name: 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite
• CAS No.: 171284-22-3
• Molecular Formula: C₂₄H₄₃N₂O₃P
• Molecular Weight: 438.591
• Mol file: 171284-22-3.mol

Synonyms:

Chemical Property of 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite

There total 1 articles about 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

bis(diisopropylamino)chlorophosphine (56183-63-2) + 2,2-dimethyl-propionic acid 4-hydroxymethyl-phenyl ester (59012-91-8) → 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite (171284-22-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1080/15257779508009491

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite (171284-22-3) → 4-pivaloyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

Guidance literature:

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1.) MeCN, 30 min, 2.) - 40 deg C - room temperature; room temperature, 5 min;

DOI:10.1080/15257779508009491

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + Dideoxyinosine (69655-05-6) + 4-pivaloyloxybenzyl bis(N,N-diisopropyl)phosphoramidite (171284-22-3) → (Rp)- and (Sp)-4-pivaloyloxybenzyl (3'-azido-3'-deoxythymidin-5-yl) (2',3'-dideoxyinosin-5'-yl) phosphate

Guidance literature:

With 1H-tetrazole; N,N-diisopropylamine tetrazolide; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction;

DOI:10.1080/15257779508009491

upstream raw materials:

bis(diisopropylamino)chlorophosphine

2,2-dimethyl-propionic acid 4-hydroxymethyl-phenyl ester

Refernces