(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Base Information

Chemical Name:(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester
CAS No.:137586-56-2
Molecular Formula:C₄₄H₅₃FNO₅PSi
Molecular Weight:753.966
Hs Code.:

(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

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Chemical Property of (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

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Technology Process of (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

There total 14 articles about (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122253-14-9
6-Cyclohexyl-4-(4-fluorophenyl)-2-(1-methylethyl)-3-pyridinemethanol

: 137586-56-2
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

2: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 50 min, 2.) THF, hexane, -78 deg C, 30 min

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00113a019

Reference yield:

: 122252-78-2
6-Cyclohexyl-4-(4-fluorophenyl)-2-(1-methylethyl)-3-pyridinecarboxylic acid, ethyl ester

: 137586-56-2
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

2: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

3: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 50 min, 2.) THF, hexane, -78 deg C, 30 min

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00113a019

Reference yield:

: 122252-64-6
2-[3-Cyclohexyl-1-(4-fluoro-phenyl)-3-oxo-propyl]-4-methyl-3-oxo-pentanoic acid ethyl ester

: 137586-56-2
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[6-cyclohexyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

2: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

3: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

4: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 50 min, 2.) THF, hexane, -78 deg C, 30 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; ammonium acetate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019