9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one

Base Information

Chemical Name:9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one
CAS No.:688045-93-4
Molecular Formula:C₃₆H₃₄N₂O₁₀S
Molecular Weight:686.739
Hs Code.:

9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4<i>H</i>-1,3-dioxa-5-aza-benzo[<i>a</i>]cyclopenta[<i>e</i>]cycloocten-11-one

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Chemical Property of 9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one

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Technology Process of 9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one

There total 9 articles about 9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 3-benzyloxy-4-{2-[(4R,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethyl}-5-nitrobenzoate

: 688045-93-4
9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one

Guidance literature:: Multi-step reaction with 9 steps

1: 9.8 g / pyridine; DMAP / 3 h / 20 °C

2: 65 percent / H₂ / Pt/C / methanol / 52 h / 20 °C / 760 Torr

3: 73 percent / pyridine / 1 h / 20 °C

4: TBAF / tetrahydrofuran / 41 h / 20 °C

5: 1.15 g / Ph₃P; DEAD / benzene; toluene / 1 h / 20 °C

6: DIBAL / CH₂Cl₂; toluene / 1.25 h / -78 °C

7: 21.2 g / Ph₃P; DEAD / benzene; toluene / 0.33 h / 20 °C

8: 72 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

9: Me₂NH*HCl; Et₃N / H₂O; propan-2-ol / 4.5 h / 90 °C

With pyridine; dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; N,N-dimethylammonium chloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; toluene; benzene; 8: Swern oxidation;
DOI:10.1021/jo049862z

Reference yield:

: 438547-26-3
methyl 4-{(2R)-2-acetoxy-2-[(4S,5R)-5-(tert-butyldimethylsilyloxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl}-3-benzyloxy-5-nitrobenzoate

: 688045-93-4
9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one

Guidance literature:: Multi-step reaction with 8 steps

1: 65 percent / H₂ / Pt/C / methanol / 52 h / 20 °C / 760 Torr

2: 73 percent / pyridine / 1 h / 20 °C

3: TBAF / tetrahydrofuran / 41 h / 20 °C

4: 1.15 g / Ph₃P; DEAD / benzene; toluene / 1 h / 20 °C

5: DIBAL / CH₂Cl₂; toluene / 1.25 h / -78 °C

6: 21.2 g / Ph₃P; DEAD / benzene; toluene / 0.33 h / 20 °C

7: 72 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

8: Me₂NH*HCl; Et₃N / H₂O; propan-2-ol / 4.5 h / 90 °C

With pyridine; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; N,N-dimethylammonium chloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; toluene; benzene; 7: Swern oxidation;
DOI:10.1021/jo049862z

Reference yield:

: 150-76-5
4-methoxy-phenol

: 688045-93-4
9-benzyloxy-7-(4-methoxy-phenoxymethyl)-2,2-dimethyl-10-methylene-5-(2-nitro-benzenesulfonyl)-3a,5,10,11a-tetrahydro-4H-1,3-dioxa-5-aza-benzo[a]cyclopenta[e]cycloocten-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: 21.2 g / Ph₃P; DEAD / benzene; toluene / 0.33 h / 20 °C

2: 72 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3: Me₂NH*HCl; Et₃N / H₂O; propan-2-ol / 4.5 h / 90 °C

With oxalyl dichloride; N,N-dimethylammonium chloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; water; isopropyl alcohol; toluene; benzene; 2: Swern oxidation;
DOI:10.1021/jo049862z