Technology Process of 3-{3-[(4-methoxyphenyl)ethyl]-1-phenyl-1H-indol-5-yl}propanoic acid tromethamine salt
There total 7 articles about 3-{3-[(4-methoxyphenyl)ethyl]-1-phenyl-1H-indol-5-yl}propanoic acid tromethamine salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: copper(I) bromide; potassium carbonate; potassium hydroxide; copper diacetate / 140 °C
2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube
3.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C
3.2: 3 h / 20 °C
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
4.2: pH 1
5.1: hydrazine; potassium hydroxide / ethylene glycol / 120 - 200 °C
5.2: pH 1
6.1: water; tetrahydrofuran / 20 °C
With
aluminum (III) chloride; copper diacetate; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; copper(I) bromide; sodium hydroxide; hydrazine;
In
tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol;
2.1: |Heck Reaction / 3.1: |Friedel-Crafts Acylation / 3.2: |Friedel-Crafts Acylation / 5.1: |Wolff-Kishner-Huang Minlon Reduction;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube
2.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C
2.2: 3 h / 20 °C
3.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
3.2: pH 1
4.1: hydrazine; potassium hydroxide / ethylene glycol / 120 - 200 °C
4.2: pH 1
5.1: water; tetrahydrofuran / 20 °C
With
aluminum (III) chloride; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; sodium hydroxide; hydrazine;
In
tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol;
1.1: |Heck Reaction / 2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation / 4.1: |Wolff-Kishner-Huang Minlon Reduction;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: copper(I) bromide; potassium carbonate; potassium hydroxide; copper diacetate / 140 °C
2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube
3.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C
3.2: 3 h / 20 °C
4.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
4.2: pH 1
5.1: hydrazine; potassium hydroxide / ethylene glycol / 120 - 200 °C
5.2: pH 1
6.1: water; tetrahydrofuran / 20 °C
With
aluminum (III) chloride; copper diacetate; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; copper(I) bromide; sodium hydroxide; hydrazine;
In
tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol;
2.1: |Heck Reaction / 3.1: |Friedel-Crafts Acylation / 3.2: |Friedel-Crafts Acylation / 5.1: |Wolff-Kishner-Huang Minlon Reduction;
DOI:10.1021/jm500494y
