2-CHLORO-6-METHOXY-4-QUINOLINECARBOXYLICACID

Base Information

• Chemical Name: 2-CHLORO-6-METHOXY-4-QUINOLINECARBOXYLICACID
• CAS No.: 20335-34-6
• Molecular Formula: C₁₁H₈ClNO₃
• Molecular Weight: 237.642
• Mol file: 20335-34-6.mol

Synonyms:

Chemical Property of 2-CHLORO-6-METHOXY-4-QUINOLINECARBOXYLICACID

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-6-METHOXY-4-QUINOLINECARBOXYLICACID

There total 6 articles about 2-CHLORO-6-METHOXY-4-QUINOLINECARBOXYLICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dihydro-6-methoxy-2-oxoquinoline-4-carboxylic acid (32431-29-1) → 4-Carboxy-6-methoxy-2-chlor-chinolin (20335-34-6)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1248/cpb.40.1322

Reference yield:

2-chloro-6-methoxy-quinoline-4-carboxylic acid ethyl ester (5345-56-2) → 4-Carboxy-6-methoxy-2-chlor-chinolin (20335-34-6)

Guidance literature:

With sodium hydroxide;

Reference yield:

N-(4-methoxyphenyl)-N-methylacetamide (35813-38-8) → 4-Carboxy-6-methoxy-2-chlor-chinolin (20335-34-6)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether; sodium ethylate / Behandeln des Reaktionsgemisches mit konz.Schwefelsaeure

2: concentrated H₂SO₄

3: PCl₅; POCl₃

4: aqueous NaOH

With sodium hydroxide; diethyl ether; phosphorus pentachloride; sulfuric acid; sodium ethanolate; trichlorophosphate;

upstream raw materials:

2-chloro-6-methoxy-quinoline-4-carboxylic acid ethyl ester

1,2-dihydro-6-methoxy-2-oxoquinoline-4-carboxylic acid

N-(4-methoxyphenyl)-N-methylacetamide

ethyl 6-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate

Downstream raw materials:

2-Hydroxychininsaeure

2-Hydroxychininsaeureethylester