2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester

Base Information

• Chemical Name: 2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester
• CAS No.: 874007-62-2
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 874007-62-2.mol

Synonyms:

Chemical Property of 2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester

There total 1 articles about 2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenoxybutyl iodide (20549-72-8) + ethyl acetoacetate (141-97-9) → 2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester (874007-62-2)

Guidance literature:

With ethanol; sodium ethanolate;

DOI:10.1021/ja01111a520

Reference yield:

2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester (874007-62-2) → 7-phenoxy-heptan-2-one (855900-29-7)

Guidance literature:

With sodium hydroxide; Erwaermen des Reaktionsprodukts mt wss. Schwefelsaeure;

DOI:10.1021/ja01111a520

Reference yield:

2-(4-phenoxy-butyl)-acetoacetic acid ethyl ester (874007-62-2) → 2-cyano-3-methyl-8-phenoxy-octanoic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution / Erwaermen des Reaktionsprodukts mt wss. Schwefelsaeure

2: ammonium acetate; acetic acid; ethanol / Hydrogenation_.Reagens 4: Palladium/Kohle

With ammonium acetate; sodium hydroxide; ethanol; acetic acid;

DOI:10.1021/ja01111a520

upstream raw materials:

4-phenoxybutyl iodide

ethyl acetoacetate

Downstream raw materials:

7-phenoxy-heptan-2-one