cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate

Base Information

Chemical Name:cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate
CAS No.:1192836-44-4
Molecular Formula:C₂₂H₂₈N₄O₄S
Molecular Weight:444.555
Hs Code.:

Synonyms:

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Chemical Property of cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate

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Technology Process of cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate

There total 5 articles about cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1021943-48-5
cyclopentyl (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoate

: 1192836-44-4
cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate

Guidance literature:: Multi-step reaction with 5 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate / palladium diacetate / acetonitrile / 48 h / 77 °C / Inert atmosphere

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 22 h / 65 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 22 h / 75 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2.17 h / 0 - 20 °C

5: hydrogen; acetic acid / palladium 10% on activated carbon / methanol

With hydrogenchloride; hydrogen; potassium acetate; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1192836-29-5
cyclopentyl (2S,4E)-2-[(tert-butoxycarbonyl)amino]-5-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pent-4-enoate

: 1192836-44-4
cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 22 h / 75 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2.17 h / 0 - 20 °C

3: hydrogen; acetic acid / palladium 10% on activated carbon / methanol

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane;

Reference yield:

: 90600-20-7
(2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid

: 1192836-44-4
cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 3 h / 0 °C

2: tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate / palladium diacetate / acetonitrile / 48 h / 77 °C / Inert atmosphere

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 22 h / 65 °C / Inert atmosphere

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 22 h / 75 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2.17 h / 0 - 20 °C

6: hydrogen; acetic acid / palladium 10% on activated carbon / methanol

With hydrogenchloride; hydrogen; potassium acetate; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; acetonitrile;