N-BETA-BOC-L-BETA-HOMOTRYPTOPHAN METHYL ESTER

Base Information

• Chemical Name: N-BETA-BOC-L-BETA-HOMOTRYPTOPHAN METHYL ESTER
• CAS No.: 348089-01-0
• Molecular Formula: C₁₈H₂₄N₂O₄
• Molecular Weight: 332.4
• Mol file: 348089-01-0.mol

Synonyms:

Chemical Property of N-BETA-BOC-L-BETA-HOMOTRYPTOPHAN METHYL ESTER

Chemical Property:

Purity/Quality:

BOC-BETA-HOMOTRP-OME 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-BETA-BOC-L-BETA-HOMOTRYPTOPHAN METHYL ESTER

There total 1 articles about N-BETA-BOC-L-BETA-HOMOTRYPTOPHAN METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S)-3-{[(tert-butoxy)carbonyl]amino}-4-(1H-indol-3-yl)butanoic acid (229639-48-9) + diazomethyl-trimethyl-silane (18107-18-1) → Nβ-tert-butoxycarbonyl-L-β-homotryptophan methyl ester (348089-01-0)

Guidance literature:

With methanol; In diethyl ether;

Reference yield:

Nβ-tert-butoxycarbonyl-L-β-homotryptophan methyl ester (348089-01-0) → C27H33N3O4

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid

1.2: 0.5 h

2.1: trifluoroacetic acid / dichloromethane / -40 - 20 °C

With trifluoroacetic acid; In dichloromethane; 2.1: |Pictet-Spengler Synthesis;

DOI:10.1002/psc.2832

Reference yield:

Nβ-tert-butoxycarbonyl-L-β-homotryptophan methyl ester (348089-01-0) → C26H31N3O4

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid

1.2: 0.5 h

2.1: trifluoroacetic acid / dichloromethane / -40 - 20 °C

With trifluoroacetic acid; In dichloromethane; 2.1: |Pictet-Spengler Synthesis;

DOI:10.1002/psc.2832

upstream raw materials:

(3S)-3-{[(tert-butoxy)carbonyl]amino}-4-(1H-indol-3-yl)butanoic acid

diazomethyl-trimethyl-silane