5-Isothiazolecarboxylic acid, 3-(4-phenoxyphenyl)-

Base Information

Chemical Name:5-Isothiazolecarboxylic acid, 3-(4-phenoxyphenyl)-
CAS No.:105769-30-0
Molecular Formula:C16H11NO3S
Molecular Weight:297.334
Hs Code.:

Synonyms:

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Chemical Property of 5-Isothiazolecarboxylic acid, 3-(4-phenoxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 5-Isothiazolecarboxylic acid, 3-(4-phenoxyphenyl)-

There total 6 articles about 5-Isothiazolecarboxylic acid, 3-(4-phenoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 105769-29-7
ethyl 3-(4-phenoxyphenyl)isothiazole-5-carboxylate

: 105769-30-0
3-(4-phenoxyphenyl)isothiazole-5-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.34.701

Reference yield:

: 67-36-7
4-phenoxy benzaldehyde

: 105769-30-0
3-(4-phenoxyphenyl)isothiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 91.3 percent / ammonium acetate / benzene; acetic acid / 2 h / Heating; Dean-Stark apparatus

2: NaOH / H₂O / 40 h / Heating

3: 1.) NH₂OH*HCl, NaOEt; 2.) Ac₂O / 1.) H₂O, EtOH, reflux, 1 h; 2.) reflux, 1 h

5: 69 percent / isoamyl nitrite / tetrahydrofuran / 0.5 h / Heating

6: 88 percent / KOH / aq. ethanol / 0.5 h / Ambient temperature

With ammonium acetate; potassium hydroxide; sodium hydroxide; hydroxylamine hydrochloride; sodium ethanolate; acetic anhydride; isopentyl nitrite; In tetrahydrofuran; ethanol; water; acetic acid; benzene;
DOI:10.1248/cpb.34.701

Reference yield:

: 92163-15-0
1-cyanomethyl-4-phenoxybenzene

: 105769-30-0
3-(4-phenoxyphenyl)isothiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

2: 69 percent / isoamyl nitrite / tetrahydrofuran / 0.5 h / Heating

3: 88 percent / KOH / aq. ethanol / 0.5 h / Ambient temperature

With potassium hydroxide; isopentyl nitrite; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.34.701