(R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride

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Chemical Name:(R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride
CAS No.:1293995-59-1
Molecular Formula:C₂₂H₂₀F₃N₅O₃*ClH
Molecular Weight:495.889
Hs Code.:

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Chemical Property of (R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride

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Technology Process of (R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride

There total 9 articles about (R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1294041-42-1
C₂₃H₂₂F₃N₅O₃

: 1293995-59-1
(R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 20 °C

2: triethylamine; lithium hydroxide / dichloromethane

With hydrogenchloride; triethylamine; lithium hydroxide; In dichloromethane;
DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

: 1293995-74-0
C₁₀H₁₆N₄O₂

: 1293995-59-1
(R)-3-amino-1-(3-(4-(carboxyl)phenyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: dimethyl sulfoxide / 150 °C

2: N-Bromosuccinimide / acetonitrile / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / Reflux; Inert atmosphere

4: trifluoroacetic acid / dichloromethane

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

6: trifluoroacetic acid / dichloromethane

7: hydrogenchloride / 20 °C

8: triethylamine; lithium hydroxide / dichloromethane

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 3: Suzuky-Miyaura coupling;
DOI:10.1016/j.bmcl.2011.01.086